Valproic Acid induces CYP3A4 and MDR1 genes expression by activation of Constitutive Androstane Receptor and Pregnane X Receptor pathways
نویسندگان
چکیده
Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove (L.C., L.S., F.S., P.P.), Institute of Medical Chemistry and Biochemistry (E.A., R.V., Z.D., J.U.), and Department of Pharmacology (P.A.), Faculty of Medicine, Palacky University, Olomouc, Czech Republic DMD Fast Forward. Published on March 28, 2007 as doi:10.1124/dmd.106.014456
منابع مشابه
Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
In our study, we tested the hypothesis whether valproic acid (VPA) in therapeutic concentrations has potential to affect expression of CYP3A4 and MDR1 via constitutive androstane receptor (CAR) and pregnane X receptor (PXR) pathways. Interaction of VPA with CAR and PXR nuclear receptors was studied using luciferase reporter assays, real-time reverse transcriptase polymerase chain reaction (RT-P...
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Chicken xenobiotic receptor, pregnane X receptor, and constitutive androstane receptor are orphan nuclear receptors that have recently been discovered to regulate drug- and steroid-mediated induction of hepatic cytochromes P450 (CYP). This induction is part of an adaptive response involving numerous genes to exposure to drugs and chemicals and has major clinical and toxicological implications. ...
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